Use of Cystatin C to Assess Kidney Function
Conclusions
August 2011
In conclusion, blood levels of cystatin C reflect GFR better than blood levels of creatinine alone. However, equations that use creatinine and demographics to predict an estimated GFR perform about as well as cystatin C alone. Elevated cystatin C levels identify patients at greater risk of CKD progression and early death, largely from cardiovascular morbidity. And finally, in the hospital setting cystatin C levels may be a better indicator of GFR, and levels of cystatin C may increase earlier than creatinine among patients that experience acute kidney injury. Thank you.
Conclusions |
Jump to section:
- Introduction
- A Case
- Questions
- What do the kidneys do?
- Why Measure Renal Function?
- How Is Chronic Kidney Disease (CKD) Defined?
- Stages of Chronic Kidney Disease
- Laboratory Assessment of Kidney Function: What Can We Measure?
- Creatinine as a Marker of GFR
- Creatinine as a Marker of GFR: It Works But...
- How Can We Turn the Serum Creatinine Into a Better Estimate of GFR?
- Revised eGFR Equation (ID-MS version)
- eGFR Equation Works, But it's Not Perfect
- What About Cystatin C?
- Mayo Renal Laboratory Cystatin C By Particle Enhanced Turbidometric Immunoassay (PETIA)
- Comparison To Current Nephelometric Assay (PENIA) Reveals 23% Bias
- Cystatin C PENIA Assay Shift (19%)
- Cystatin C eGFR Using Published Equation* Performs Well3
- Cystatin C Equations Categorize Patients Slightly Better Than MDRD eGFR
- Cystatin C Reference Range
- PETIA Cystatin C Reference Range
- Cystatin C: Useful To Confirm Those At Risk Of CKD Progression And Its Complications (REGARDS)4
- Cystatin C: CKD Progression and Complications (MESA and CHS)5
- Cystatin C in the Acute Hospitalized Setting6
- Back to Our Patient
- Potential Interventions
- Conclusions
- References
- Questions?
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