Use of Cystatin C to Assess Kidney Function
Currently, our reference ranges for infants and children up to 17 years of age are based on literature values, as shown on the slide. The adult values were obtained from the reference range study shown the previous slide. Our current 95% reference range is 0.488 to 1.134 mg/L, with a mean of 0.71 mg/L. There were no gender differences apparent in our study. However, we are currently evaluating additional samples to determine if the reference range should be slightly higher for those greater than 50 years of age. Of note, other large epidemiological studies have suggested that cystatin C levels do increase in older individuals.
PETIA Cystatin C Reference Range
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- A Case
- What do the kidneys do?
- Why Measure Renal Function?
- How Is Chronic Kidney Disease (CKD) Defined?
- Stages of Chronic Kidney Disease
- Laboratory Assessment of Kidney Function: What Can We Measure?
- Creatinine as a Marker of GFR
- Creatinine as a Marker of GFR: It Works But...
- How Can We Turn the Serum Creatinine Into a Better Estimate of GFR?
- Revised eGFR Equation (ID-MS version)
- eGFR Equation Works, But it's Not Perfect
- What About Cystatin C?
- Mayo Renal Laboratory Cystatin C By Particle Enhanced Turbidometric Immunoassay (PETIA)
- Comparison To Current Nephelometric Assay (PENIA) Reveals 23% Bias
- Cystatin C PENIA Assay Shift (19%)
- Cystatin C eGFR Using Published Equation* Performs Well3
- Cystatin C Equations Categorize Patients Slightly Better Than MDRD eGFR
- Cystatin C Reference Range
- PETIA Cystatin C Reference Range
- Cystatin C: Useful To Confirm Those At Risk Of CKD Progression And Its Complications (REGARDS)4
- Cystatin C: CKD Progression and Complications (MESA and CHS)5
- Cystatin C in the Acute Hospitalized Setting6
- Back to Our Patient
- Potential Interventions