Use of Cystatin C to Assess Kidney Function
Cystatin C Equations Categorize Patients Slightly Better Than MDRD eGFR
August 2011
We also calculated MDRD estimated GFR from serum creatinine in the same population. In general, both equations performed reasonably well. However cystatin C. estimated GFR was more specific for identifying patients with a borderline reduction in GFR between 60 and 80 ml/min/1.73m2, shown in the highlighted region on the table. Therefore, cystatin C may have particular utility for providing accurate estimates of GFR among patients with stages 1 and 2 CKD, and for not misdiagnosing normal patients with CKD.
Cystatin C Equations Better |
Jump to section:
- Introduction
- A Case
- Questions
- What do the kidneys do?
- Why Measure Renal Function?
- How Is Chronic Kidney Disease (CKD) Defined?
- Stages of Chronic Kidney Disease
- Laboratory Assessment of Kidney Function: What Can We Measure?
- Creatinine as a Marker of GFR
- Creatinine as a Marker of GFR: It Works But...
- How Can We Turn the Serum Creatinine Into a Better Estimate of GFR?
- Revised eGFR Equation (ID-MS version)
- eGFR Equation Works, But it's Not Perfect
- What About Cystatin C?
- Mayo Renal Laboratory Cystatin C By Particle Enhanced Turbidometric Immunoassay (PETIA)
- Comparison To Current Nephelometric Assay (PENIA) Reveals 23% Bias
- Cystatin C PENIA Assay Shift (19%)
- Cystatin C eGFR Using Published Equation* Performs Well3
- Cystatin C Equations Categorize Patients Slightly Better Than MDRD eGFR
- Cystatin C Reference Range
- PETIA Cystatin C Reference Range
- Cystatin C: Useful To Confirm Those At Risk Of CKD Progression And Its Complications (REGARDS)4
- Cystatin C: CKD Progression and Complications (MESA and CHS)5
- Cystatin C in the Acute Hospitalized Setting6
- Back to Our Patient
- Potential Interventions
- Conclusions
- References
- Questions?
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