Use of Cystatin C to Assess Kidney Function
Since cystatin C production is not greatly influenced by patient demographics, equations to estimate GFR using cystatin C are simpler. Shown on this slide is 1 equation developed using the PETIA assay. Note that there are no variables for age, race, body size, or gender. Recently we evaluated 107 persons in the renal function lab who are having clinically indicated GFR measurements by iothalamate clearance. We also measured blood cystatin C and creatinine to calculate their estimated GFR. Shown here is the good comparison between measured GFR and cystatin C estimated GFR. In general, there is a very good correlation, without significant bias across the GFR range.
Cystatin C eGFR Using Published Equation*3
Jump to section:
- A Case
- What do the kidneys do?
- Why Measure Renal Function?
- How Is Chronic Kidney Disease (CKD) Defined?
- Stages of Chronic Kidney Disease
- Laboratory Assessment of Kidney Function: What Can We Measure?
- Creatinine as a Marker of GFR
- Creatinine as a Marker of GFR: It Works But...
- How Can We Turn the Serum Creatinine Into a Better Estimate of GFR?
- Revised eGFR Equation (ID-MS version)
- eGFR Equation Works, But it's Not Perfect
- What About Cystatin C?
- Mayo Renal Laboratory Cystatin C By Particle Enhanced Turbidometric Immunoassay (PETIA)
- Comparison To Current Nephelometric Assay (PENIA) Reveals 23% Bias
- Cystatin C PENIA Assay Shift (19%)
- Cystatin C eGFR Using Published Equation* Performs Well3
- Cystatin C Equations Categorize Patients Slightly Better Than MDRD eGFR
- Cystatin C Reference Range
- PETIA Cystatin C Reference Range
- Cystatin C: Useful To Confirm Those At Risk Of CKD Progression And Its Complications (REGARDS)4
- Cystatin C: CKD Progression and Complications (MESA and CHS)5
- Cystatin C in the Acute Hospitalized Setting6
- Back to Our Patient
- Potential Interventions