Use of Cystatin C to Assess Kidney Function
The Mayo Clinic renal laboratory has recently evaluated a new cystatin C assay. It is a particle-enhanced turbidometric immunoassay, or PETIA, and can be run on a chemistry autoanalyzer. This confers certain lab advantages including high-capacity, quick turnaround time, and lower-cost compared to other platforms. Importantly, this assay is also standardized to a cystatin C international reference material. Our validation studies revealed very low within and between run coefficient of variations of 0.65-1.33%. The lower limit of quantification was 0.35 mg per liter, with an upper range of 6 mg per liter.
Cystatin C By PETIA
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- A Case
- What do the kidneys do?
- Why Measure Renal Function?
- How Is Chronic Kidney Disease (CKD) Defined?
- Stages of Chronic Kidney Disease
- Laboratory Assessment of Kidney Function: What Can We Measure?
- Creatinine as a Marker of GFR
- Creatinine as a Marker of GFR: It Works But...
- How Can We Turn the Serum Creatinine Into a Better Estimate of GFR?
- Revised eGFR Equation (ID-MS version)
- eGFR Equation Works, But it's Not Perfect
- What About Cystatin C?
- Mayo Renal Laboratory Cystatin C By Particle Enhanced Turbidometric Immunoassay (PETIA)
- Comparison To Current Nephelometric Assay (PENIA) Reveals 23% Bias
- Cystatin C PENIA Assay Shift (19%)
- Cystatin C eGFR Using Published Equation* Performs Well3
- Cystatin C Equations Categorize Patients Slightly Better Than MDRD eGFR
- Cystatin C Reference Range
- PETIA Cystatin C Reference Range
- Cystatin C: Useful To Confirm Those At Risk Of CKD Progression And Its Complications (REGARDS)4
- Cystatin C: CKD Progression and Complications (MESA and CHS)5
- Cystatin C in the Acute Hospitalized Setting6
- Back to Our Patient
- Potential Interventions