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Use of Cystatin C to Assess Kidney Function



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Creatinine as a Marker of GFR

Slide 9

August 2011

Serum creatinine is a tried and true marker of GFR. Creatinine is a byproduct of muscle turnover. In general, production of creatinine is very constant from day-to-day in any given individual. Exceptions would include situations where muscle is rapidly damaged such as rhabdomyolysis, or individuals that greatly increase or decrease muscle mass over time. Creatinine is a very small molecule that is freely filtered in the kidney. Hence, clearance of creatinine is proportionate to GFR. However, it is well established that a small amount of creatinine is also secreted by kidney tubules. Therefore, creatinine clearance will always overestimate GFR to some extent. Furthermore muscle mass varies greatly between individuals depending on their age, gender, and size.

Creatinine as a Marker of GFR

 


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