Use of Cystatin C to Assess Kidney Function
Why Measure Renal Function?
August 2011
Therefore, clinicians need accurate ways to estimate this key number. The most important reason is to screen patients for the presence of chronic kidney disease, so that appropriate treatment can be initiated. If a person is known to have chronic kidney disease, then clinicians will want to monitor GFR over time to determine if kidney function is remaining stable or not. If GFR falls too low, then plans need to be made for renal replacement therapy, such as dialysis or transplantation. Finally, certain drugs are eliminated by the kidney, and doses need to be reduced when GFR falls below certain thresholds. Typically GFR is reported not in liters per day, but in milliliters per minute. Furthermore, it is now standard to normalize this number for body surface size, or 1.73 m2.
Why Measure Renal Function? |
Jump to section:
- Introduction
- A Case
- Questions
- What do the kidneys do?
- Why Measure Renal Function?
- How Is Chronic Kidney Disease (CKD) Defined?
- Stages of Chronic Kidney Disease
- Laboratory Assessment of Kidney Function: What Can We Measure?
- Creatinine as a Marker of GFR
- Creatinine as a Marker of GFR: It Works But...
- How Can We Turn the Serum Creatinine Into a Better Estimate of GFR?
- Revised eGFR Equation (ID-MS version)
- eGFR Equation Works, But it's Not Perfect
- What About Cystatin C?
- Mayo Renal Laboratory Cystatin C By Particle Enhanced Turbidometric Immunoassay (PETIA)
- Comparison To Current Nephelometric Assay (PENIA) Reveals 23% Bias
- Cystatin C PENIA Assay Shift (19%)
- Cystatin C eGFR Using Published Equation* Performs Well3
- Cystatin C Equations Categorize Patients Slightly Better Than MDRD eGFR
- Cystatin C Reference Range
- PETIA Cystatin C Reference Range
- Cystatin C: Useful To Confirm Those At Risk Of CKD Progression And Its Complications (REGARDS)4
- Cystatin C: CKD Progression and Complications (MESA and CHS)5
- Cystatin C in the Acute Hospitalized Setting6
- Back to Our Patient
- Potential Interventions
- Conclusions
- References
- Questions?
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