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Von Willebrand Disease (VWD)
Part 4: VWF Multimer Analysis

The Role of von Willebrand Factor Multimer Analysis in Diagnosis



VWF Multimers Analysis: Summary (2)

Slide 37

July 2011

Von Willebrand factor multimer analysis should be performed only reflexively after initial screening tests such as von Willebrand factor antigen and activity are found to be reduced or have an abnormal ratio as outlined in the von Willebrand disease profile. There are certainly selected clinical conditions such as in patients with myeloproliferative disorders, hypertrophic obstructive cardiomyopathy or aortic stenosis where multimer analysis may be useful despite normal results of von Willebrand factor assays. However, the cutoffs for von Willebrand factor activity to antigen ratio validated during development of the von Willebrand disease profile have been set to be highly sensitive for detection of a acquired abnormalities of von Willebrand factor.

VWF Multimers Analysis: Summary (2)

 


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