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Von Willebrand Disease (VWD)
Part 4: VWF Multimer Analysis

The Role of von Willebrand Factor Multimer Analysis in Diagnosis



Type 2B VWD

Slide 34

July 2011

The next patient also had a disproportionate reduction in von Willebrand factor activity assays compared to the von Willebrand factor antigen and there was an absence of the high molecular weight multimers; this patient was also thrombocytopenic and therefore fit the diagnostic criteria for type 2B von Willebrand disease. Patients with type 2 von Willebrand disease generally do not respond to desmopressin, in fact desmopressin is contraindicated in patients with type 2B von Willebrand disease. Management will therefore consist of use of von Willebrand factor concentrates for prevention and management of hemorrhage.

Type 2B VWD

 


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