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Von Willebrand Disease (VWD)
Part 4: VWF Multimer Analysis

The Role of von Willebrand Factor Multimer Analysis in Diagnosis



Type 3 VWD

Slide 32

July 2011

In the next case, this patient had markedly reduced von Willebrand factor levels. As a result of such marked reduction, factor VIII activity was also reduced. These data suggest either a severe type 1 or a type 3 von Willebrand disease. Analysis of this patient’s von Willebrand factor multimers essentially demonstrated absent von Willebrand factor multimers. Given the virtual absence of von Willebrand factor multimers, we do not attempt a desmopressin trial. Prevention and management of minor or major hemorrhage for patients with this type of von Willebrand disease would consist of von Willebrand factor concentrates.

Type 3 VWD

 


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