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Von Willebrand Disease (VWD)
Part 4: VWF Multimer Analysis

The Role of von Willebrand Factor Multimer Analysis in Diagnosis



VWF Multimer Imaging: Autoradiography vs Infrared In-gel Immunostaining

Slide 24

July 2011

After the electrophoresis is completed, the gels containing patient von Willebrand factor are subject to multiple incubation and washing steps as shown on the slide. As you can see on the right, our original radioactive method resulted in a processing time of approximately 7 to 9 days. With our developmental efforts, using an infrared-based system, processing time has been reduced to approximately 4 days, and has also eliminated the need for radioactive reagents.

VWF Multimer Imaging

 


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