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Von Willebrand Disease (VWD)
Part 4: VWF Multimer Analysis

The Role of von Willebrand Factor Multimer Analysis in Diagnosis

Indication for VWF multimer analysis

Slide 15

July 2011

Let us address the question of why von Willebrand factor multimer analysis needs to be performed. As you can see, the main reason to perform von Willebrand factor multimer analysis is to sub-type von Willebrand disease. The main clinically relevant distinction is between type 1 von Willebrand disease and what I like to term the non-type 1 von Willebrand disease, that is the type 2 variants and type 3 von Willebrand disease. This distinction has therapeutic implications. For the type 1 von Willebrand disease, desmopressin or DDAVP, which may be administered by intravenous or intranasal route, may be an option for prevention or treatment of minor hemorrhage. For most type 2 variants and all patients with type 3 von Willebrand disease, von Willebrand factor containing clotting factor concentrates are the treatment of choice.

Indication for VWF multimer analysis


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