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Von Willebrand Disease (VWD)
Part 4: VWF Multimer Analysis

The Role of von Willebrand Factor Multimer Analysis in Diagnosis

23-Year-Old Female

Slide 14

July 2011

Coming back to our patient, as you can see, her von Willebrand factor antigen and activity were reduced as was the ristocetin cofactor activity, the latter assay is generally performed only for samples with reduced von Willebrand factor activity. The FVIII activity was normal, thus excluding a homozygous carrier state for von Willebrand disease Type 2 N or Normandy subtype. Based on these criteria outlined in the von Willebrand disease profile, von Willebrand factor multimer analysis was subsequently performed.

23-Year-Old Female


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