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Von Willebrand Disease (VWD)
Part 4: VWF Multimer Analysis

The Role of von Willebrand Factor Multimer Analysis in Diagnosis

Activated Platelets: Disrupted Vascular Lumen

Slide 8

July 2011

However, in the setting of a damaged vascular endothelium, subendothelial von Willebrand factor is exposed to circulating platelets, and binds to the constitutively activated glycoprotein Ib alpha platelet receptor. This binding action exerts a torque on the platelet, as it is briskly carried forward by flowing blood, and this results in platelet activation. Consequences include activation of multiple platelet receptors and secretion of intracellular contents which leads to recruitment of other platelets. All these actions culminate in platelet adhesion and aggregation resulting in formation of a platelet plug at sites of vascular injury. Simultaneous activation of the coagulation cascade results in formation of a stable hemostatic plug held in place by a fibrin clot. Thus, von Willebrand factor has an important role in platelet plug formation, in addition, von Willebrand factor acts as a carrier protein for FVIII, protecting it from proteolytic degradation.

Activated Platelets: Disrupted Lumen


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