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Von Willebrand Disease (VWD)
Part 4: VWF Multimer Analysis

The Role of von Willebrand Factor Multimer Analysis in Diagnosis

Inactive Platelets With Intact Endothelial Wall

Slide 7

July 2011

We will next focus on the physiologic role of von Willebrand factor in primary hemostasis. As you can see from this slide, von Willebrand factor is not only present in plasma, but is also present in the subendothelial tissue and in platelets. Normally, platelets are circulating in an inactive state and are constantly bumping up against the vascular endothelium. Contact with an intact vascular endothelium does not result in platelet activation.

Inactive Platelets With Intact Endothelial Wall


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