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Von Willebrand Disease (VWD)
Part 4: VWF Multimer Analysis

The Role of von Willebrand Factor Multimer Analysis in Diagnosis



Synthesis and Catabolism of VWF

Slide 6

July 2011

Upon secretion, the ultra-large von Willebrand factor molecular weight multimer complexes undergo physiologic proteolysis by a mettaloprotease called ADAMTS-13. Thus, circulating plasma von Willebrand factor multimers reflect an equilibrium between secretion of von Willebrand factor containing large and ultra-large multimers and their cleavage into smaller derivatives which when visualized on agarose electrophoresis gels are categorized into low, intermediate and large or high molecular weight multimers.

Synthesis and Catabolism of VWF

 


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