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Von Willebrand Disease (VWD)
Part 4: VWF Multimer Analysis

The Role of von Willebrand Factor Multimer Analysis in Diagnosis



VWF: Synthesis and Multimerization

Slide 5

July 2011

Prior to secretion, these von Willebrand factor monomers undergo post-translational modifications such as glycosylation, dimerization and subsequently multimerization and propeptide cleavage ultimately resulting in secretion of von Willebrand factor peptides ranging in size from 0.6 to 20,000 kilodaltons. These are also categorized into low, intermediate, large and ultra-large molecular weight multimers.

VWF: Synthesis and Multimerization

 


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