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Von Willebrand Disease (VWD)
Part 4: VWF Multimer Analysis

The Role of von Willebrand Factor Multimer Analysis in Diagnosis



VWF Structure and Domains

Slide 4

July 2011

Von Willebrand factor is a large glycoprotein that is synthesized in endothelial cells and megakaryocytes as individual units called monomers. Shown in this slide is a schematic of von Willebrand factor peptide above and below is shown the domain structure of a von Willebrand factor monomer. As you can see, each monomer has specific domains that serve different functions such as FVIII binding or binding to different receptors, such as the glycoprotein IIb/IIIa receptor on platelets.

VWF Structure and Domains

 


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