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Von Willebrand Disease (VWD)
Part 2: NHLBI Diagnosis Guidelines

Laboratory Recommendations



Summary

Slide 29

June 2011

In summary: We think that these new VWF latex activity assay has adequate sensitivity and specificity to be used as part of an initial screening panel. It has significantly improved the precision and lower detection limit. It is more sensitive than VWF ristocetin cofactor activity assay to detect acquired VWF abnormalities due to subtle losses of the highest molecular weight multimers. We also discussed some limitations of this new assay and explained our new testing algorithm. We hope that by implementing this new VWF activity assay and VWD testing algorithm we can significantly improve the accuracy and efficiency of VWD laboratory testing.

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