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Von Willebrand Disease (VWD)
Part 3: VWF Activity Assay

A New von Willebrand Factor Activity Assay and Testing Algorithm



Sample Categorization

Slide 14

June 2011

We then categorized samples into normal, type 1, type 2 VWD, severe type 1 vs 2M VWD and acquired VWF abnormality (AVWA in abbreviation). This categorization is for method comparison. Most of them are self-explanatory. The severe type 1 versus 2M VWD categorize samples whose VWF ristocetin cofactor activities were below lower detection limit and their VWF multimer analysis showed no significant loss of high molecular weight multimers. Therefore, they can not be confidently distinguished between a severe type 1 or 2M von Willebrand disease. Acquired VWF abnormality (AVWA) categorizes samples with normal VWF antigen and ristocetin cofactor activity but have very subtle losses of highest molecular weight multimers.

Sample Categorization

 


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