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Von Willebrand Disease (VWD)
Part 3: VWF Activity Assay

A New von Willebrand Factor Activity Assay and Testing Algorithm



VWF:RCo is Inadequate for Detecting AVW Abnormality

Slide 8

June 2011

We studied 23 patients who received left ventricular assist device implantation and 1 patient with polycythemia vera and marked thrombocytosis. All patients had subtle losses of the highest molecular weight VWF multimers. By using the receiver operating characteristic curve analysis, we studied the sensitivity and specificity of VWF ristocetin cofactor activity over antigen ratio. The area under the curve (AUC) is 0.75. When a 0.7 is set as the cut-off, its sensitivity of detecting such acquired VWF abnormality is less than 50%.

Detecting AVW Abnormality

 


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