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Von Willebrand Disease (VWD)
Part 3: VWF Activity Assay

A New von Willebrand Factor Activity Assay and Testing Algorithm



VWF:RCo/Ag Ratio is Insensitive for Aquired von Willebrand Abnormalities (AVWA)

Slide 7

June 2011

Now let us look at acquired VWF abnormalities. Here are 2 patients; patient A was status post left ventricular assist device implantation, patient B had polycythemia vera with marked thrombocytosis. Both patients had abnormal VWF multimer profile with subtle losses of the highest molecular weight multimers. Both patients had normal VWF antigen, VWF ristocetin cofactor activity and normal VWF activity over antigen ratios as listed in the table. Therefore, without a multimer analysis, the acquired VWF abnormality could easily be missed.

VWF:RCo/Ag Ratio is Insensitive for AVWA

 


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