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Guidelines for Anticoagulation Therapy for Secondary Prevention After Deep Vein Thrombosis

PROLONG: D-Dimer Testing to Determine Duration of Anticoagulation5

Slide 11

June 2011

So the use of fibrin D-Dimer has been assessed in a prospective trial called the PROLONG trial in this slide.

More than 600 patients with idiopathic venous thrombosis were treated for their thrombus for 3 months and then their warfarin was stopped. One month later, they had fibrin D-Dimer testing. If the D-Dimer was normal, then they were left off of warfarin therapy. If it was abnormal, then they were randomized to either to resume warfarin or to remain off of warfarin therapy.

Testing Duration of Anticoagulation5


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