Von Willebrand Disease (VWD)
Part 2: NHLBI Diagnosis Guidelines

VWD Profile

May 2011

Mayo Medical Laboratories (MML) and the Mayo Special Coagulation Laboratory have recently modified the test content and algorithm for the von Willebrand profile (test #83099), formerly identified as Coagulation Consultation #554: VWD panel.

For the 3 initial VWD tests, an assay of VWF activity based on automated latex immunoassay (LIA) has replaced the VWF ristocetin cofactor assay for screening purposes – because it has been extensively validated as an improvement for screening purposes as well as for supplemental VWD testing. Samples found to have decreased VWF antigen or VWF activity (LIA), or an abnormal ratio of these results, are reflexively evaluated by performing VWF ristocetin cofactor assay as well as VWF multimer analysis, followed by an interpretation of the overall profile test results. In 2 related MML “Hot Topic” presentations on VWD and VWF, my colleagues, Drs. Dong Chen and Rajiv Pruthi, will further discuss this testing algorithm, especially focusing on the VWF activity assay and the VWF multimer analysis.

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Jump to section:

• Introduction
• Objectives—Part 2
• VWD NHLBI Guidelines (2008)¹
• VWD Classification — ISTH^1,2
• VWD NHLBI Guidelines (2008) Initial Patient Evaluation — Laboratory¹
• VWD NHLBI Guidelines 2008 Initial Patient Evaluation — Laboratory¹
• VWD — Initial Laboratory Evaluation
• VWD NHLBI Guidelines (2008) Subsequent Patient Evaluation—Laboratory¹
• Additional VWD Testing — Laboratory¹
• VWF Multimer Analysis: Intermediate Resolution³
• VWF Multimer Analysis: Recommendations⁴
• VWF Multimer Analysis: Recommendations⁴
• Expected Laboratory Values in VWD¹
• Typical Patterns of Laboratory Test Results for VWD Diagnosis and Classification¹
• VWD NHLBI Guidelines (2008) "Low VWF" versus "VWD Type 1"
• VWD Diagnosis (Especially Type 1)
• VWD NHLBI Guidelines ABO Blood Group & VWF/VWD^1,5
• VWD NHLBI Guidelines ABO Blood Group and VWF/VWD: Soft Recommendations
• VWD NHLBI Guidelines (2008): Collection and Handling of Samples for Laboratory Testing¹
• VWD NHLBI Guidelines (2008): Collection and Handling of Samples for Laboratory Testing¹
• VWD NHLBI Guidelines (2008): Collection and Handling of Samples for Laboratory Testing¹
• VWD NHLBI Guidelines: Collection and Handling of Samples for Laboratory Testing^1,4
• VWD NHLBI Guidelines (2008) Summary of Laboratory Recommendations
• VWD NHLBI Guidelines (2008) Summary of Laboratory Recommendations
• References
• VWD Profile
• Questions?