Von Willebrand Disease (VWD)
Part 2: NHLBI Diagnosis Guidelines

VWD NHLBI Guidelines ABO Blood Group & VWF/VWD^1,5

May 2011

This table from the NHLBI VWD Guidelines summarizes results of an important study about the major influence of ABO blood grouping on plasma VWF levels – published in 1987 by investigators from the Blood Center and the associated Hemophilia Center in Milwaukee, Wisconsin. Firstly, among patients with type 1 VWD there was an over-representation of those with blood group O: 77% had group O compared to the expected 45%. This identified that the clinical diagnosis of type 1 VWD occurs much more frequently in those inheriting blood group O, compared to other ABO blood groups. And, the information implies that co-inheriting both blood group O and type 1 VWD trait makes it more likely that the individual will manifest significantly low VWF and bleeding symptoms (ie, type 1 VWD). A second implication of these results is that reference ranges for VWF values (eg, VWF antigen) can be stratified by ABO blood grouping, with group O having the lowest values (as low as about 40 IU/dL, with mean values at least 25% lower than those for other ABO groups), for apparently normal blood donors. Subsequent research has identified that the VWF protein has ABO blood group carbohydrate antigens; and that the in vivo survival (biologic half-life) of VWF in blood is decreased in persons with blood group O (normal persons or those with VWD).

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Jump to section:

• Introduction
• Objectives—Part 2
• VWD NHLBI Guidelines (2008)¹
• VWD Classification — ISTH^1,2
• VWD NHLBI Guidelines (2008) Initial Patient Evaluation — Laboratory¹
• VWD NHLBI Guidelines 2008 Initial Patient Evaluation — Laboratory¹
• VWD — Initial Laboratory Evaluation
• VWD NHLBI Guidelines (2008) Subsequent Patient Evaluation—Laboratory¹
• Additional VWD Testing — Laboratory¹
• VWF Multimer Analysis: Intermediate Resolution³
• VWF Multimer Analysis: Recommendations⁴
• VWF Multimer Analysis: Recommendations⁴
• Expected Laboratory Values in VWD¹
• Typical Patterns of Laboratory Test Results for VWD Diagnosis and Classification¹
• VWD NHLBI Guidelines (2008) "Low VWF" versus "VWD Type 1"
• VWD Diagnosis (Especially Type 1)
• VWD NHLBI Guidelines ABO Blood Group & VWF/VWD^1,5
• VWD NHLBI Guidelines ABO Blood Group and VWF/VWD: Soft Recommendations
• VWD NHLBI Guidelines (2008): Collection and Handling of Samples for Laboratory Testing¹
• VWD NHLBI Guidelines (2008): Collection and Handling of Samples for Laboratory Testing¹
• VWD NHLBI Guidelines (2008): Collection and Handling of Samples for Laboratory Testing¹
• VWD NHLBI Guidelines: Collection and Handling of Samples for Laboratory Testing^1,4
• VWD NHLBI Guidelines (2008) Summary of Laboratory Recommendations
• VWD NHLBI Guidelines (2008) Summary of Laboratory Recommendations
• References
• VWD Profile
• Questions?