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Von Willebrand Disease (VWD)
Part 2: NHLBI Diagnosis Guidelines

Laboratory Recommendations

VWD NHLBI Guidelines ABO Blood Group & VWF/VWD1,5

Slide 17

May 2011

This table from the NHLBI VWD Guidelines summarizes results of an important study about the major influence of ABO blood grouping on plasma VWF levels – published in 1987 by investigators from the Blood Center and the associated Hemophilia Center in Milwaukee, Wisconsin. Firstly, among patients with type 1 VWD there was an over-representation of those with blood group O: 77% had group O compared to the expected 45%. This identified that the clinical diagnosis of type 1 VWD occurs much more frequently in those inheriting blood group O, compared to other ABO blood groups. And, the information implies that co-inheriting both blood group O and type 1 VWD trait makes it more likely that the individual will manifest significantly low VWF and bleeding symptoms (ie, type 1 VWD). A second implication of these results is that reference ranges for VWF values (eg, VWF antigen) can be stratified by ABO blood grouping, with group O having the lowest values (as low as about 40 IU/dL, with mean values at least 25% lower than those for other ABO groups), for apparently normal blood donors. Subsequent research has identified that the VWF protein has ABO blood group carbohydrate antigens; and that the in vivo survival (biologic half-life) of VWF in blood is decreased in persons with blood group O (normal persons or those with VWD).

ABO Blood Group & VWF/VWD1,5


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