Von Willebrand Disease (VWD)
Part 2: NHLBI Diagnosis Guidelines

Typical Patterns of Laboratory Test Results for VWD Diagnosis and Classification¹

May 2011

This table, modified from the NHLBI VWD Guidelines, summarizes information from the previous slide (14), but in a different way and with some numerical values assigned.

The most commonly performed VWD tests are listed in the column headings across the top, and various types of VWD are listed in the left-hand column. The NHLBI VWD Guidelines expert panel recommended 30 IU/dL as the value, below which, VWD diagnosis can be definitely supported by laboratory testing results – especially for type 1 VWD (which lacks laboratory test result characteristics that clearly distinguish it from "mildly low VWF" or "possible type 1 VWD" [circled at the bottom left]). Other characteristic test results – that especially help distinguish among the various VWD subtypes – are also highlighted with circles.

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Typical Patterns of Laboratory Test Results1

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Jump to section:

• Introduction
• Objectives—Part 2
• VWD NHLBI Guidelines (2008)¹
• VWD Classification — ISTH^1,2
• VWD NHLBI Guidelines (2008) Initial Patient Evaluation — Laboratory¹
• VWD NHLBI Guidelines 2008 Initial Patient Evaluation — Laboratory¹
• VWD — Initial Laboratory Evaluation
• VWD NHLBI Guidelines (2008) Subsequent Patient Evaluation—Laboratory¹
• Additional VWD Testing — Laboratory¹
• VWF Multimer Analysis: Intermediate Resolution³
• VWF Multimer Analysis: Recommendations⁴
• VWF Multimer Analysis: Recommendations⁴
• Expected Laboratory Values in VWD¹
• Typical Patterns of Laboratory Test Results for VWD Diagnosis and Classification¹
• VWD NHLBI Guidelines (2008) "Low VWF" versus "VWD Type 1"
• VWD Diagnosis (Especially Type 1)
• VWD NHLBI Guidelines ABO Blood Group & VWF/VWD^1,5
• VWD NHLBI Guidelines ABO Blood Group and VWF/VWD: Soft Recommendations
• VWD NHLBI Guidelines (2008): Collection and Handling of Samples for Laboratory Testing¹
• VWD NHLBI Guidelines (2008): Collection and Handling of Samples for Laboratory Testing¹
• VWD NHLBI Guidelines (2008): Collection and Handling of Samples for Laboratory Testing¹
• VWD NHLBI Guidelines: Collection and Handling of Samples for Laboratory Testing^1,4
• VWD NHLBI Guidelines (2008) Summary of Laboratory Recommendations
• VWD NHLBI Guidelines (2008) Summary of Laboratory Recommendations
• References
• VWD Profile
• Questions?