Von Willebrand Disease (VWD)
Part 2: NHLBI Diagnosis Guidelines

VWD NHLBI Guidelines 2008 Initial Patient Evaluation — Laboratory¹

May 2011

These 3 initial tests for VWD (VWF antigen, ristocetin cofactor activity, factor VIII) not only screen for VWD (or help exclude it), but are used to assist in classifying VWD if it is present (eg, differentiating type 1 from types 2 or 3 VWD) – this is a Grade B, level III recommendation. The reference standards for these 3 tests are critical and should be referenced to the World Health Organization (WHO) standard. If referenced to the WHO standard, these 3 test results can or should be reported in IU (international units) – where IU/dL is equivalent to % (the latter [%] is commonly used for reporting coagulation factor levels relative to the mean normal level).

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Jump to section:

• Introduction
• Objectives—Part 2
• VWD NHLBI Guidelines (2008)¹
• VWD Classification — ISTH^1,2
• VWD NHLBI Guidelines (2008) Initial Patient Evaluation — Laboratory¹
• VWD NHLBI Guidelines 2008 Initial Patient Evaluation — Laboratory¹
• VWD — Initial Laboratory Evaluation
• VWD NHLBI Guidelines (2008) Subsequent Patient Evaluation—Laboratory¹
• Additional VWD Testing — Laboratory¹
• VWF Multimer Analysis: Intermediate Resolution³
• VWF Multimer Analysis: Recommendations⁴
• VWF Multimer Analysis: Recommendations⁴
• Expected Laboratory Values in VWD¹
• Typical Patterns of Laboratory Test Results for VWD Diagnosis and Classification¹
• VWD NHLBI Guidelines (2008) "Low VWF" versus "VWD Type 1"
• VWD Diagnosis (Especially Type 1)
• VWD NHLBI Guidelines ABO Blood Group & VWF/VWD^1,5
• VWD NHLBI Guidelines ABO Blood Group and VWF/VWD: Soft Recommendations
• VWD NHLBI Guidelines (2008): Collection and Handling of Samples for Laboratory Testing¹
• VWD NHLBI Guidelines (2008): Collection and Handling of Samples for Laboratory Testing¹
• VWD NHLBI Guidelines (2008): Collection and Handling of Samples for Laboratory Testing¹
• VWD NHLBI Guidelines: Collection and Handling of Samples for Laboratory Testing^1,4
• VWD NHLBI Guidelines (2008) Summary of Laboratory Recommendations
• VWD NHLBI Guidelines (2008) Summary of Laboratory Recommendations
• References
• VWD Profile
• Questions?