Von Willebrand Disease (VWD)
Part 1: NHLBI Diagnosis Guidelines

Introduction

March 2011

Welcome to Mayo Medical Laboratories' Hot Topics. These presentations provide short discussions of current topics and may be helpful to you in your practice.

Our presenter for this program is William L. Nichols, MD, consultant in the Special Coagulation Laboratory and Hemophilia Center at Mayo Clinic in Rochester, Minnesota. In Part 1 of this 2-part presentation, Dr. Nichols will provide a brief overview of von Willebrand disease (VWD) and summarize recommendations for clinical assessment for VWD, primarily based on guidelines from the National Heart, Lung, and Blood Institute expert panel.

Thank you for tuning in for Mayo Medical Laboratories' Hot Topics series on von Willebrand disease (VWD). For this first of two short presentations on VWD Diagnosis Guidelines, I will initially provide an introduction about von Willebrand factor (VWF) and hereditary VWD, as well as a summary about acquired von Willebrand syndrome (AVWS). Since VWD diagnosis involves synthesizing both clinical and laboratory assessments, I will then focus on discussing guidelines for the clinical evaluation for VWD. My discussion will be mainly based on the evidence-based guidelines from the National Heart, Lung, and Blood Institute (NHLBI) expert panel report in 2008. In the subsequent presentation (Part 2) I will focus on a discussion of guidelines for the laboratory evaluation for VWD.

Introduction

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Jump to section:

• Objectives — Part 1
• VWF Biology
• VWF and Normal Hemostasis¹
• VWF Structure and Domains¹
• VWD Classification — ISTH^1,2
• VWD: Prevalence, Inheritance, Symptoms
• Disorders Pathophysiologically Associated with Acquired von Willebrand Syndrome (AVWS)³
• VWD NHLBI Guidelines — Background
• NHLBI VWD Expert Panel
• Methodology
• Methodology
• Overall Outcome / Results
• Initial Clinical Evaluation for VWD or Other Bleeding Disorders¹
• Common Bleeding Symptoms of Healthy Persons vs. VWD Patients¹
• VWD NHLBI Guidelines (2008)¹Initial Patient Evaluation — History⁴
• VWD NHLBI Guidelines (2008) Initial Patient Evaluation — History
• Initial Patient Evaluation — History
• VWD NHLBI Guidelines (2008)
• References
• Questions?