Von Willebrand Disease (VWD)
Part 1: NHLBI Diagnosis Guidelines

Overall Outcome / Results

May 2011

The final NHLBI VWD Guidelines document cited about 400 selected references. It included sections on scientific background and overview, clinical and laboratory diagnosis, treatment and management, and opportunities and needs. The document has 17 Tables, 6 Figures, and 13 Evidence Tables (for Grade B recommendations with 2 or more published studies). There are approximately 54 evidence-based graded recommendations, for diagnosis or for management, but none are grade A recommendations (reflecting a paucity of evidence from randomized controlled trials). The evidence-based recommendations are approximately equally divided into those of grade B (based on published evidence at levels II and III) and grade C (mainly based on expert opinions at level IV). There are many additional "soft" (un-numbered) recommendations throughout the document, based primarily on expert opinions and/or limited evidence.

The NHLBI VWD Guidelines include a caveat that these guidelines and recommendations do not abrogate professional judgment in individual cases.

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Jump to section:

• Introduction
• Objectives — Part 1
• VWF Biology
• VWF and Normal Hemostasis¹
• VWF Structure and Domains¹
• VWD Classification — ISTH^1,2
• VWD: Prevalence, Inheritance, Symptoms
• Disorders Pathophysiologically Associated with Acquired von Willebrand Syndrome (AVWS)³
• VWD NHLBI Guidelines — Background
• NHLBI VWD Expert Panel
• Methodology
• Methodology
• Overall Outcome / Results
• Initial Clinical Evaluation for VWD or Other Bleeding Disorders¹
• Common Bleeding Symptoms of Healthy Persons vs. VWD Patients¹
• VWD NHLBI Guidelines (2008)¹Initial Patient Evaluation — History⁴
• VWD NHLBI Guidelines (2008) Initial Patient Evaluation — History
• Initial Patient Evaluation — History
• VWD NHLBI Guidelines (2008)
• References
• Questions?