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Serologic Testing for Syphilis


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Slide 20

April 2011

Before we wrap up, I just wanted to make a few additional concluding remarks. First, routine screening for syphilis in healthy, pregnant women should be performed by RPR or an IgG-based treponemal assay. Including syphilis IgM testing in healthy, asymptomatic patients increases the potential for false-positive results. Second, the pretest probability is critical when ordering and interpreting syphilis serology. In other words, you should always question and investigate positive results in patients without symptoms and in patients with low risk and low pretest probability of disease. And finally, it is imperative that health care providers perform a thorough historical and clinical evaluation following positive syphilis serology results so that an accurate interpretation can be made.



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