Serologic Testing for Syphilis

Conclusions

April 2011

In summary, the traditional serology algorithm, which includes a nontreponemal screening test followed by a treponemal confirmatory test, is still recommended in high-incidence settings. However, the reverse algorithm is widely used due to advantages in specificity and laboratory workflow. When a treponemal test is used for screening, a nontreponemal should be performed on screen-positive samples to assess the patient’s disease and treatment status. And a second treponemal test, such as the TP-PA assay, should be used on samples with discordant screen-positive, but RPR-negative results.

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• Introduction
• Presentation Outline
• Syphilis — The "Great Imitator"
• Diagnosis: Laboratory Testing
• Diagnosis: Nontreponemal Serology Tests
• Diagnosis: Treponemal Serology Tests
• Diagnosis: Traditional Algorithm
• Diagnosis: Traditional Algorithm
• Syphilis — Incidence
• Syphilis — Incidence
• Diagnosis: Contemporary Algorithm
• Diagnosis: Contemporary Algorithm
• Diagnosis: Proposed Algorithm with Treponemal Screening Test
• Interpretation and Follow-up
• Interpretation and Follow-up
• Interpretation and Follow-up
• Interpretation and Follow-up
• Interpretation and Follow-up
• Conclusions
• Conclusions
• Questions?