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Serologic Testing for Syphilis


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Interpretation and Follow-up

Slide 17

April 2011

In the fourth scenario, a patient with unknown history tests positive by the treponemal screening assay, negative by RPR, but is also positive by the second-tier treponemal test. These results could be consistent with several different interpretations, depending on the historical and clinical evaluation. If the patient has been treated in the past with an antimicrobial with anti-Treponemal activity, these results could be suggestive of past, successfully treated disease. However, if the patient lacks any treatment history, these results may be consistent with latent syphilis, which may require treatment. These varying interpretations stress the importance of a thorough historical and clinical evaluation in patients with these results.

Interpretation and Follow-up


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