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Serologic Testing for Syphilis


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Interpretation and Follow-up

Slide 16

April 2011

In the third scenario, a patient with no history, or an unknown history, of syphilis tests positive by the screening treponemal assay, but the reflex testing by RPR is reported as negative. In this situation, a second treponemal test is performed on the same serum sample and is reported as negative. These results would be consistent with a false-positive screening test, and no further testing is required unless clinically indicated. I should highlight that the second treponemal test should be a different method than the one used for screening, and the CDC has recently recommended that TP-PA be used to resolve discordant screening treponemal and RPR results.

Interpretation and Follow-up


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