Serologic Testing for Syphilis

Diagnosis: Traditional Algorithm

April 2011

As I mentioned, this traditional algorithm has been in place for decades and has several advantages, including the fact that it is a reliable method, especially in high-prevalence settings. In addition, this algorithm utilizes a rapid, inexpensive screening method that is economical and easily implemented in most hospitals and small clinics. However, this approach has limitations, including a low throughput and subjective interpretation of the screening RPR results. This subjectivity, along with the fact that RPR detects mainly non-specific antibodies can translate into higher rates of false-positive results, especially in low-incidence settings.

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Diagnosis: Traditional Algorithm

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Jump to section:

• Introduction
• Presentation Outline
• Syphilis — The "Great Imitator"
• Diagnosis: Laboratory Testing
• Diagnosis: Nontreponemal Serology Tests
• Diagnosis: Treponemal Serology Tests
• Diagnosis: Traditional Algorithm
• Diagnosis: Traditional Algorithm
• Syphilis — Incidence
• Syphilis — Incidence
• Diagnosis: Contemporary Algorithm
• Diagnosis: Contemporary Algorithm
• Diagnosis: Proposed Algorithm with Treponemal Screening Test
• Interpretation and Follow-up
• Interpretation and Follow-up
• Interpretation and Follow-up
• Interpretation and Follow-up
• Interpretation and Follow-up
• Conclusions
• Conclusions
• Questions?