Circulating Tumor Cells and the CellSearch Assay

Introduction

March 2011

Welcome to Mayo Medical Laboratories' Hot Topics. These presentations provide short discussions of current topics and may be helpful to you in your practice.

Our presenters for this program are Kevin Halling, MD, PhD and Michael Campion from the Division of Laboratory Genetics and Anatomic Pathology at Mayo Clinic. Dr. Halling will provide an overview of the metastatic process in cancer and how circulating tumor cell counts influence prognosis and overall survival in metastatic breast, colorectal, or prostate cancer. Mike Campion will discuss the technical aspects of a novel assay for enumerating circulating tumor cells in peripheral blood and cite several clinical trial studies describing the clinical utility of this assay.

Mike Campion and I are going to discuss the use of the Cell Search assay for the detection of circulating tumor cells. We believe that circulating tumor cell analysis is a valuable new tool for monitoring patients with metastatic cancer and that it will be increasingly used in the clinical management of patients with metastatic cancer.

Introduction

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Jump to section:

• Circulating Tumor Cell (CTC)
• The Metastatic Process
• Needle in a Haystack...
• Circulating Tumor Cells
• The CellSearch System (Veridex LLC)
• Automated Sample Preparation
• Labeling and Identification of CTCs
• Labeling and Identification of Cells
• Cell Analysis
• Mayo Medical Laboratories FDA-Cleared Assays
• Metastatic Breast Cancer (MBC)
• CellSearch Use in MBC Clinical Trial⁶
• Progression-Free Survival in MBC
• Overall Survival in MBC
• Metastatic Colorectal Cancer (MCRC)
• CellSearch Use in MCRC Clinical Trial⁸
• Progression-Free Survival in MCRC
• Overall Survival in MCRC
• Metastatic Prostate Cancer (MPC)
• CellSearch Use in MPC Clinical Trial⁸
• Progression-Free Survival in MPC
• Overall Survival in MPC
• The Future of CTC
• References
• Questions?