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Circulating Tumor Cells and the CellSearch Assay



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Overall Survival in MPC

Slide 23

April 2011

Kaplan-Meier analyses were also performed to determine whether circulating tumor cell counts could predict overall survival. The graph on the left shows that when comparing the favorable and unfavorable groups, the median overall survival was shown to be significantly longer in the favorable group than in the unfavorable group (21.7 months versus 11.5 months).

The graph on the right shows that those patients with =5 CTC at any point after the initiation of therapy had a much higher likelihood of dying sooner. Patients with =5 CTC at all time points had the shortest median overall survival, which was significantly different compared to the median overall survival for the group that a rising CTC count. Finally, this graph also demonstrates that patients who showed a decrease in CTC count improve their survival chances and had a median overall survival similar to those patients with favorable CTC count at all draws. The figure also shows that unfavorable CTC levels after the initiation of therapy significantly decreased overall survival.

Overall Survival in MPC

 


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