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Circulating Tumor Cells and the CellSearch Assay


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Overall Survival in MBC

Slide 15

April 2011

Kaplan-Meier analyses were also performed to determine whether circulating tumor cell counts could predict overall survival. The graph on the left shows that when comparing the favorable and unfavorable groups, the median overall survival was shown to be significantly longer in the favorable group than in the unfavorable group (21.9 versus 10.9 months).

The graph on the right shows that metastatic breast cancer patients who had =5 CTCs at all timepoints after the initiation of therapy had a much shorter overall survival of 4.1 months. Whereas those patients that were less than 5 CTCs at all time points had the longest overall survival of 22.6 months. Interestingly, those patients who have = 5 CTCs at baseline but eventually decreased to less than 5 CTCs after the start of therapy have approximately the same risk of death as those who never exceed the 5 circulating tumor cells threshold.

This led to the FDA approval of the CellSearch system for use in metastatic breast cancer patients in 2004.

Overall Survival in MBC


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