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Circulating Tumor Cells and the CellSearch Assay



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CellSearch Use in MBC Clinical Trial6

Slide 13

April 2011

A multicenter, prospective, longitudinal clinical trial using the CellSearch system was conducted between 2001 and 2003, and the results published in 4 scientific publications. The summary of these results can be seen in this chart. The trial included 177 patients with metastatic disease as defined by standard imaging techniques. Results were used to determine whether the number of circulating tumor cells predicted disease progression and survival in metastatic breast cancer patients. A baseline circulating tumor cell count was determined prior to start of new therapy and an initial follow-up count was determined after the start of therapy. Progression-free survival was determined from the time of the baseline draw to identifiable disease progression based on CT scans or clinical indications. Overall survival was measured from baseline blood draw to the time of death. Lets take a look at these results a little more closely on the next few slides.

CellSearch Use in MBC Clinical Trial6

 


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