Circulating Tumor Cells and the CellSearch Assay

Metastatic Breast Cancer (MBC)

April 2011

In 2010, an estimated 209,000 new cases of breast cancer were diagnosed in the United States and approximately 40,000 deaths from this disease. Of newly diagnosed cases of breast cancer, 5% of patients will have metastatic breast cancer at diagnosis, and another 30% will ultimately develop metastatic disease. With these numbers, it is easy to see how an assay that could monitor the metastatic process would be very useful.

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Metastatic Breast Cancer (MBC)

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Jump to section:

• Introduction
• Circulating Tumor Cell (CTC)
• The Metastatic Process
• Needle in a Haystack...
• Circulating Tumor Cells
• The CellSearch System (Veridex LLC)
• Automated Sample Preparation
• Labeling and Identification of CTCs
• Labeling and Identification of Cells
• Cell Analysis
• Mayo Medical Laboratories FDA-Cleared Assays
• Metastatic Breast Cancer (MBC)
• CellSearch Use in MBC Clinical Trial⁶
• Progression-Free Survival in MBC
• Overall Survival in MBC
• Metastatic Colorectal Cancer (MCRC)
• CellSearch Use in MCRC Clinical Trial⁸
• Progression-Free Survival in MCRC
• Overall Survival in MCRC
• Metastatic Prostate Cancer (MPC)
• CellSearch Use in MPC Clinical Trial⁸
• Progression-Free Survival in MPC
• Overall Survival in MPC
• The Future of CTC
• References
• Questions?