Circulating Tumor Cells and the CellSearch Assay

Cell Analysis

April 2011

The final step in the identification of a circulating tumor cell is done by a review of images by a technologist. The technologist reviews the gallery of images and selects those images that fit the criteria of an intact tumor cell, which once again is EpCam positive, cytokeratin positive and DAPI positive. Once that is complete, a pathologist reviews the selections and makes any changes that he or she feels is warranted.

< Previous Slide

Cell Analysis

Next Slide >

 

Jump to section:

• Introduction
• Circulating Tumor Cell (CTC)
• The Metastatic Process
• Needle in a Haystack...
• Circulating Tumor Cells
• The CellSearch System (Veridex LLC)
• Automated Sample Preparation
• Labeling and Identification of CTCs
• Labeling and Identification of Cells
• Cell Analysis
• Mayo Medical Laboratories FDA-Cleared Assays
• Metastatic Breast Cancer (MBC)
• CellSearch Use in MBC Clinical Trial⁶
• Progression-Free Survival in MBC
• Overall Survival in MBC
• Metastatic Colorectal Cancer (MCRC)
• CellSearch Use in MCRC Clinical Trial⁸
• Progression-Free Survival in MCRC
• Overall Survival in MCRC
• Metastatic Prostate Cancer (MPC)
• CellSearch Use in MPC Clinical Trial⁸
• Progression-Free Survival in MPC
• Overall Survival in MPC
• The Future of CTC
• References
• Questions?