Circulating Tumor Cells and the CellSearch Assay

Needle in a Haystack...

April 2011

Tumors shed an enormous number of tumor cells. It is estimated that approximately one million circulating tumor cells are shed per gram of tumor tissue. However, only a small proportion of these CTCs survive. Within 24 hours, less than 0.1% of these cells are still viable and less than 0.01% survive to produce metastases. Patients with metastatic cancer have been found to have approximately 1 tumor cell per 100,000 to 10 million mononuclear cells in their peripheral blood.

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Jump to section:

• Introduction
• Circulating Tumor Cell (CTC)
• The Metastatic Process
• Needle in a Haystack...
• Circulating Tumor Cells
• The CellSearch System (Veridex LLC)
• Automated Sample Preparation
• Labeling and Identification of CTCs
• Labeling and Identification of Cells
• Cell Analysis
• Mayo Medical Laboratories FDA-Cleared Assays
• Metastatic Breast Cancer (MBC)
• CellSearch Use in MBC Clinical Trial⁶
• Progression-Free Survival in MBC
• Overall Survival in MBC
• Metastatic Colorectal Cancer (MCRC)
• CellSearch Use in MCRC Clinical Trial⁸
• Progression-Free Survival in MCRC
• Overall Survival in MCRC
• Metastatic Prostate Cancer (MPC)
• CellSearch Use in MPC Clinical Trial⁸
• Progression-Free Survival in MPC
• Overall Survival in MPC
• The Future of CTC
• References
• Questions?