Circulating Tumor Cells and the CellSearch Assay

The Metastatic Process

April 2011

This slide provides an overview of the metastatic process. The metastatic process begins when a cancer cell breaks away from a tumor and enters the lymphatic or peripheral bloodstream. At some point a circulating tumor cell then comes to rest against a vessel wall and extravasates into the surrounding tissue. This circulating tumor cell may then establish a new tumor at a site distant from the original tumor, in other words a metastasis. Tumor angiogenesis helps establish the new tumor.

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The Metastatic Process

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Jump to section:

• Introduction
• Circulating Tumor Cell (CTC)
• The Metastatic Process
• Needle in a Haystack...
• Circulating Tumor Cells
• The CellSearch System (Veridex LLC)
• Automated Sample Preparation
• Labeling and Identification of CTCs
• Labeling and Identification of Cells
• Cell Analysis
• Mayo Medical Laboratories FDA-Cleared Assays
• Metastatic Breast Cancer (MBC)
• CellSearch Use in MBC Clinical Trial⁶
• Progression-Free Survival in MBC
• Overall Survival in MBC
• Metastatic Colorectal Cancer (MCRC)
• CellSearch Use in MCRC Clinical Trial⁸
• Progression-Free Survival in MCRC
• Overall Survival in MCRC
• Metastatic Prostate Cancer (MPC)
• CellSearch Use in MPC Clinical Trial⁸
• Progression-Free Survival in MPC
• Overall Survival in MPC
• The Future of CTC
• References
• Questions?