Circulating Tumor Cells and the CellSearch Assay

Circulating Tumor Cell (CTC)

April 2011

A circulating tumor cell is a cell that has detached from a solid tumor and entered the peripheral bloodstream. A number of studies have now demonstrated that the presence of circulating tumor cells in the peripheral blood is associated with decreased progression-free survival and decreased overall survival in patients with metastatic breast, colorectal, or prostate cancer. Mike will review the findings of some of these studies later in this presentation.

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Circulating Tumor Cell (CTC)

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Jump to section:

• Introduction
• Circulating Tumor Cell (CTC)
• The Metastatic Process
• Needle in a Haystack...
• Circulating Tumor Cells
• The CellSearch System (Veridex LLC)
• Automated Sample Preparation
• Labeling and Identification of CTCs
• Labeling and Identification of Cells
• Cell Analysis
• Mayo Medical Laboratories FDA-Cleared Assays
• Metastatic Breast Cancer (MBC)
• CellSearch Use in MBC Clinical Trial⁶
• Progression-Free Survival in MBC
• Overall Survival in MBC
• Metastatic Colorectal Cancer (MCRC)
• CellSearch Use in MCRC Clinical Trial⁸
• Progression-Free Survival in MCRC
• Overall Survival in MCRC
• Metastatic Prostate Cancer (MPC)
• CellSearch Use in MPC Clinical Trial⁸
• Progression-Free Survival in MPC
• Overall Survival in MPC
• The Future of CTC
• References
• Questions?