Maternal Serum Screening
Down Syndrome, Trisomy 18 and Neural Tube Defects
First Trimester Serum Screening
March 2011
Moving on to each type of screening, first trimester screening is performed between 10 and 14 weeks of gestation. It provides a risk for Down syndrome and trisomy 18.
The markers used on the risk calculation are 2 serum markers: Pregnancy-associated plasma protein A (PAPP-A) and human chorionic gonadotropin or hCG. Decreased levels of PAPP-A before the 14th week of gestation are associated with an increased risk for Down syndrome and trisomy 18. Whereas increased levels of hCG are associated with an increased risk of Down syndrome. The third marker is the fetal nuchal translucency which is performed by ultrasound.
First Trimester Serum Screening |
Jump to section:
- Introduction
- What is Maternal Serum Screening?
- Who Should Be Offered Maternal Serum Screening?
- Maternal Serum Screening: Options
- Maternal Serum Screening: Risk Calculation
- First Trimester Serum Screening
- Nuchal Translucency (NT)
- Nuchal Translucency (NT)
- Nuchal Translucency (NT)
- First Trimester Serum Screening
- First Trimester Screening
- Second Trimester Screening
- Second Trimester Screening
- Second Trimester Screening
- Sequential Screening
- Sequential Screening
- Sequential Screening
- Sequential Screening
- Mayo Medical Laboratories Maternal Serum Screening Options
- References
- Questions?
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