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Maternal Serum Screening

Down Syndrome, Trisomy 18 and Neural Tube Defects

Maternal Serum Screening: Options

Slide 4

March 2011

In this presentation, I will discuss 3 options for maternal serum screening. These options are first trimester, second trimester and sequential screening. Sequential screening is a type of cross-trimester screening which uses markers from the first and second trimester screening tests. Sequential screening was introduced to increase the detection rate and decrease the false-positive rate seen with the first 2 options.

It is important to keep in mind that these 3 options are screening tests. This means that a screen-negative result does not guarantee the absence of fetal defects and a screen-positive will need additional testing to determine if a defect is present.

Maternal Serum Screening: Options


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