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Monoclonal Gammopathy of Undetermined Significance (MGUS)


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Serum Protein Electrophoresis and Immunofixation Electrophoresis

Slide 3

March 2011

The secreted immunoglobulin becomes a systemic marker of the plasma cells growing in the bone marrow, and monoclonal immunoglobulins are one of the oldest and best tumor markers that we have. In this slide we see the electrophoretic analysis of a normal serum and a serum from a patient with multiple myeloma. Each panel contains an agarose protein electrophoresis gel (or PEL) and an immunofixation electrophoresis gel (or IFE).

The normal serum in the upper panel shows a smooth electrophoretic distribution of the polyclonal immunoglobulins. The lower panel shows a dense band caused by a monoclonal IgG kappa protein. The protein electrophoretic quantitation indicates an M spike of 3.8 g/dL.

When we identify a monoclonal IgG or IgA of at least 3 g/dL, it is consistent with multiple myeloma. But not all myelomas present this way.

SP Electrophoresis and IF Electrophoresis


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