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Fungal Molecular Diagnostics

Nucleic Acid Hybridization Probes for Fungi

Slide 9

February 2011

Fungal nucleic acid hybridization probes are available for the identification of only Blastomyces dermatitidis, Coccidioides immitis, and Histoplasma capsulatum. These probes are FDA-approved products and they have excellent sensitivity and specificity as shown in the table on this slide. However, one should be mindful that the Blastomyces dermatitidis probe has the potential to cross-react with a few other fungi including Emmonsia species, Paracoccioides brasiliensis, and Gymnascella species. Generally, a review of fungal morphology and patient travel and clinical history will help to determine whether cross-reactivity is a potential issue. Of additional interest, the Coccidioides probe does not distinguish between the 2 recognized species, namely Coccidioides immitis and Coccidioides posadasii, but differentiation is typically of epidemiologic, rather than clinical, importance.

Nucleic Acid Hybridization Probes


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