Paroxysmal Nocturnal Hemoglobinuria
Interpretation and Reporting
December 2010
Based on the data from normal donors, we established reference ranges which are listed here. They are: 0.01% for type III or deficient RBCs and granulocytes, and 0.05 for monocytes. The reason for decreased monocyte sensitivity is in a relatively small number of monocytes routinely available for testing. In addition, there are situations in which we are not able to collect enough granulocytes to reach desired sensitivity, usually because of profound neutropenia of the patient. In these cases, we would indicate in our report that the specimen has low WBC count which may impact the reached sensitivity.
Interpretation and Reporting |
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- Introduction
- Paroxysmal Nocturnal Hemoglobinuria
- Prevalence
- Pathogenesis
- Paroxysmal Nocturnal Hemoglobinuria
- Progression
- New Developments
- New Developments, cont.
- Role of Laboratory Testing
- International PNH Group Recommendations: Who to Test?
- Diagnosis
- International PNH Group Recommendation: How to Test?
- Normal
- New WBC PNH
- Sensitivity and Reference Interval
- Interpretation and Reporting
- PNH—Summary
- Questions?
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