Paroxysmal Nocturnal Hemoglobinuria
Role of Laboratory Testing
December 2010
There are 3 clinical scenarios in which laboratory testing for PNH is appropriate. First, patients with clinical suspicion of having classical PNH should undergo testing for diagnostic purposes. Second, patients with established PNH diagnosis should be monitored regularly, at 1 year intervals if stable, or more frequently, particularly if on therapy. Finally, patients with suspected myelodysplasia and aplastic anemia should undergo testing for detection of small clones; small clones in aplastic anemia should be followed regularly as these clones may progress into classical PNH.
Role of Laboratory Testing |
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- Introduction
- Paroxysmal Nocturnal Hemoglobinuria
- Prevalence
- Pathogenesis
- Paroxysmal Nocturnal Hemoglobinuria
- Progression
- New Developments
- New Developments, cont.
- Role of Laboratory Testing
- International PNH Group Recommendations: Who to Test?
- Diagnosis
- International PNH Group Recommendation: How to Test?
- Normal
- New WBC PNH
- Sensitivity and Reference Interval
- Interpretation and Reporting
- PNH—Summary
- Questions?
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