Paroxysmal Nocturnal Hemoglobinuria
Progression
December 2010
Studies have shown that PIG-A mutation is not sufficient to drive survival of the clone, as cells are likely to be lysed by complement. Two proposed mechanisms for clonal progression are immunologic selection and acquisition of additional mutations; however, no definitive cause of clonal progression has been identified.
Progression |
Jump to section:
- Introduction
- Paroxysmal Nocturnal Hemoglobinuria
- Prevalence
- Pathogenesis
- Paroxysmal Nocturnal Hemoglobinuria
- Progression
- New Developments
- New Developments, cont.
- Role of Laboratory Testing
- International PNH Group Recommendations: Who to Test?
- Diagnosis
- International PNH Group Recommendation: How to Test?
- Normal
- New WBC PNH
- Sensitivity and Reference Interval
- Interpretation and Reporting
- PNH—Summary
- Questions?
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