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Paroxysmal Nocturnal Hemoglobinuria



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Progression

Slide 6

December 2010

Studies have shown that PIG-A mutation is not sufficient to drive survival of the clone, as cells are likely to be lysed by complement. Two proposed mechanisms for clonal progression are immunologic selection and acquisition of additional mutations; however, no definitive cause of clonal progression has been identified.

Progression

 


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